IMS Educational Topics

Metabolomics is a term applied to the global metabolite profiling of biological samples (particularly biofluids such as urine and plasma). It is combined with multivariate statistical analysis in order to identify changes in response to a toxic insult, disease progression or genetic modification…

Increasingly, untargeted metabolomic studies are being applied to large scale investigations, often comprising several thousands of samples obtained in toxicological, clinical and epidemiological studies. Even with the combination of sensitivity, reproducibility and throughput provided by ultra-performance liquid chromatography-mass spectrometry (UPLC-MS), there is conflict between the need for rapid analysis and the desire for complete metabolite coverage…

The application of untargeted metabolic profiling (metabolomics) to large scale preclinical metabolism/toxicological, clinical, and epidemiological investigations has delivered new insights into the underlying biology of disease and toxicology. Metabolomics has the advantage of being relatively simple and inexpensive to perform compared to genomics and provides both concentration and temporal data….