SELECT SERIES Cyclic IMS

IMS beyond your imagination

To redefine the boundaries of what’s possible, you need an instrument that not only provides ultimate performance, but also adds unique capabilities. That’s exactly what the Cyclic IMS does! Equipped with a novel set of features, it delivers the perfect experimental toolset for IMS.

Cyclic IMS Acquisitions Types

Cyclic ion mobility has a unique circular path, which enables you to define your path length by simply performing multi-pass experiments. Ions of a given mobility range can be selected and passed around the device as many times as you need, allowing you to ‘zoom in’ on analytes of interest.

Cyclic Ion Mobility Device

More mobility resolution not solving your problem? Try advanced characterization experiments with the Cyclic IMS, whereby ions are selected by their ion mobility and subsequently reinjected with collision-induced dissociation to provide unique IMSn data. This revolutionary instrument combines this cyclic ion mobility capability with the latest Tof technology, providing mass resolution that ensures you see more detail in your sample than ever before.

With so much innovation, the Cyclic is a fantastic way to bring your lab to the forefront of scientific discovery, allowing you to confidently tackle new analytical challenges. Running the Cyclic with the new-look MassLynx software and data visualization tools provides the flexibility to design custom methodologies. The only limit is your imagination!

Creative scientists are constantly expanding the number of applications for the Cyclic; some highlights include:

  • Separating and quantifying individual compounds in complex biological matrices
  • Collision induced unfolding experiments on native proteins
  • Detailed and confidently characterizing compounds in petroleomics studies

A Cyclic Ion Mobility – Mass Spectrometry System

Cyclic Ion Mobility Mass Spectrometry Distinguishes Anomers and Open-Ring Forms of Pentasaccharides

Gas Phase Stability of Protein Ions in a Cyclic Ion Mobility Spectrometry Travelling Wave Device

Investigations into the performance of travelling wave enabled conventional and cyclic ion mobility systems to characterise protomers of fluoroquinolone antibiotic residues


"I'M Standing in the home of revolutionary technology development"
Kevin Giles
Scientific Fellow Waters Corporation

At Waters, we are dedicated to supplying our customers with instruments that break the boundaries of ion mobility spectrometry (IMS). I am proud to have developed technology that is unleashing our customers’ scientific creativity and help them make life-changing discoveries.


"I'M Seeing data that will signal the start of new discoveries"
Perdita Baran
Professor of Mass Spectrometry The University of Manchester

The latest ion mobility spectrometry (IMS) technology is enabling me to see more than ever before from my sample. With this valuable tool in our arsenal, my research team can comprehensively investigate complex molecular structures and make discoveries that will help shape the future of medicine.


References:

  1. Carbohydrate Isomer Resolution via Multi-site Derivatization Cyclic Ion Mobility-Mass Spectrometry. Kristin R. McKenna,   Li Li,   Andy Baker,   Jakub Ujma,   Ramanarayanan Krishnamurthy,   Charles Liotta  and  Facundo Fernandez, DOI: 10.1039/C9AN01584A
  2. Isolation of Crude Oil Peaks Differing by ~m/z 0.1 via Tandem Mass Spectrometry using a Cyclic Ion Mobility-Mass Spectrometer. Eunji Cho, Eleanor Riches, Martin Palmer, Kevin Giles, Jakub Ujma, Sunghwan Kim, https://doi.org/10.1021/acs.analchem.9b02255
  3. Historical, Current and Future Developments of Traveling Wave Ion Mobility Mass Spectrometry: A Personal Perspective, Iain D.G. Campuzano, Kevin Giles, PII: S0165-9936(18)30715-5, DOI: https://doi.org/10.1016/j.trac.2019.115620, Reference: TRAC 115620.
  4. Structure Determination of Large Isomeric Oligosaccharides of Natural Origin through Multipass and Multistage Cyclic Traveling-Wave Ion Mobility Mass Spectrometry. Ropartz D, Fanuel M, Ujma J, Palmer M, Giles K, Rogniaux H. Anal Chem. 2019 Sep 17;91(18):12030-12037. doi: 10.1021/acs.analchem.9b03036. Epub 2019 Sep 3. PMID: 31449397
  5. Discrimination of Regioisomeric and Stereoisomeric Saponins from Aesculus hippocastanum Seeds by Ion Mobility Mass Spectrometry. Colson E, Decroo C, Cooper-Shepherd D, Caulier G, Henoumont C, Laurent S, De Winter J, Flammang P, Palmer M, Claereboudt J, Gerbaux P. J Am Soc Mass Spectrom. 2019 Aug 26. doi: 10.1007/s13361-019-02310-7.
  6. A Cyclic Ion Mobility-Mass Spectrometry System. Giles K, Ujma J, Wildgoose J, Pringle S, Richardson K, Langridge D, Green M. Anal Chem. 2019 Jul 2;91(13):8564-8573. doi: 10.1021/acs.analchem.9b01838. Epub 2019 Jun 12.
  7. Gas Phase Stability of Protein Ions in a Cyclic Ion Mobility Spectrometry Traveling Wave Device. Eldrid C, Ujma J, Kalfas S, Tomczyk N, Giles K, Morris M, Thalassinos K. Anal Chem. 2019 Jun 18;91(12):7554-7561. doi: 10.1021/acs.analchem.8b05641. Epub 2019 Jun 5.
  8. Cyclic Ion Mobility Mass Spectrometry Distinguishes Anomers and Open-Ring Forms of Pentasaccharides. Ujma J, Ropartz D, Giles K, Richardson K, Langridge D, Wildgoose J, Green M, Pringle S. J Am Soc Mass Spectrom. 2019 Jun;30(6):1028-1037. doi: 10.1007/s13361-019-02168-9. Epub 2019 Apr 11.
  9. Investigations into the performance of travelling wave enabled conventional and cyclic ion mobility systems to characterise protomers of fluoroquinolone antibiotic residues. McCullagh M, Giles K, Richardson K, Stead S, Palmer M. Rapid Commun Mass Spectrom. 2018 Dec 14. doi: 10.1002/rcm.8371.
  10. Multiple Gas-Phase Conformations of a Synthetic Linear Poly(acrylamide) Polymer Observed Using Ion Mobility-Mass Spectrometry. Haler JRN, Far J, Aqil A, Claereboudt J, Tomczyk N, Giles K, Jérôme C, De Pauw E. J Am Soc Mass Spectrom. 2017 Nov;28(11):2492-2499. doi: 10.1007/s13361-017-1769-x. Epub 2017 Aug 14.
  11. Ion mobility-mass spectrometry: time-dispersive instrumentation. May JC, McLean JA. Anal Chem. 2015 Feb 3;87(3):1422-36. doi: 10.1021/ac504720m. Epub 2015 Jan 9.
  12. High-Resolution Ion Mobility Spectrometry-Mass Spectrometry of Isomeric/Isobaric Ribonucleotide Variants. Kenderdine T, Nemati R, Baker A, Palmer M, Ujma J, Fitzgibbon M, Deng L, Royzen M, Langridge J, Fabris D. JMS. 2019 Nov 7. https://doi.org/10.1002/jms.4465.
  13. LESA cyclic ion mobility mass spectrometry of intact proteins from thin tissue sections. Sisley EK, Ujma J, Palmer M, Giles K, Francisco A, Fernandez-Lima, Cooper HJ. Analytical Chemistry. 2020 Apr 9. https://doi.org/10.1021/acs.analchem.9b05169
  14. Application of a novel cyclic ion mobility-mass spectrometer to the analysis of synthetic polymers: A preliminary evaluation. Riches E, Palmer ME. Rapid Communications in Mass Spectrometry. 2019 Dec 19. https://doi.org/10.1002/rcm.8710