SYNAPT XS High Resolution Mass Spectrometer

IMS with ultimate flexibility

The SYNAPT XS is an all-in-one system solution, providing the versatility to future-proof your lab. With optimized technological building blocks and ion mobility capability, it delivers powerful performance. Stepwave XS improves the instrument’s overall sensitivity, whilst providing increased transmission of labile ions. The adaptable operation of the tripartite Triwave IMS cell, combined with rapid acquisition of CCS measurements, provides an added dimension of molecular definition, greatly enhancing your ability to confidently identify and characterize components. In addition, the extended Tof flight path length adds an extra dimension of mass resolution essential for dissecting the most complex of mixtures.

The SYNAPT XS also provides a large variety of acquisition modes which grants users the freedom to choose appropriate analytical strategies fitting to their application. Analyzing samples with complementary data-independent acquisition (DIA) techniques, including SONAR and HDMSE, increases peak capacity, providing clean and clear fragmentation data. With these capabilities, the SYNAPT XS delivers a unique investigative toolbox for the characterization of complex samples.

The inherent experimental flexibility makes the SYNAPT XS system solution the smart choice to enable discovery and characterization across all areas of industry.  Applications include:

  • Increasing depth of coverage in proteomic experiments with SONAR
  • Gaining extra confidence in the identification of isomeric species in lipidomics, proteomics and metabolomics

Read more about the applications of IMS-MS here.

Analysis of Plasma Proteome for a Respiratory Disease Cohort Using SONAR on a SYNAPT XS Mass Spectrometer

(Sign in required)

Characteristics of Proteomics Experiments Performed on the SYNAPT XS Q-ToF Mass Spectrometer

"I'M Speaking about powerful spatial visualization technology."
Laura Cole
Senior Lecturer in Biomedical Science (FHEA) Sheffield Hallam University

Ion mobility spectrometry (IMS) separation provides me with the power I need to separate target molecules within mass spectrometry imaging experiments. By leveraging the latest IMS technologies, my team can now confidently study diseased tissues to inform the development of world-changing treatments.